You are being redirectedNot a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. Advisory Committee to the Director. Enhancing the protection of human subjects in gene transfer research at the National Institutes of Health. July
Recombinant DNA Technology in Emerging Modalities for Melanoma Immunotherapy
Melanoma - From Early Detection to Treatment. The history of immunotherapy of cancer dates back to s when New York surgeon William Coley used Streptococcus and Serratia bacterial extracts to treat cancer. Better understanding of the human immune system led to the identification of a number of tumor-associated antigens TAAs in the s [ 1 ] and development of various immunotherapeutic approaches. Of particular relevance to melanoma immunotherapy was the identification of various antigens expressed specifically in melanocytes and, respectively, in the majority of melanomas. These and several other melanoma-associated antigens formed the basis for the immunologic targeting of the tumor. Up to date, multiple peptide, dendritic cell, adjuvant, lymphocyte, antibody, DNA and virus-based strategies were tested in pre-clinical and clinical studies with varying degrees of success.
In the past century, the recombinant DNA technology was just an imagination that desirable characteristics can be improved in the living bodies by controlling the expressions of target genes. However, in recent era, this field has demonstrated unique impacts in bringing advancement in human life. By virtue of this technology, crucial proteins required for health problems and dietary purposes can be produced safely, affordably, and sufficiently. This technology has multidisciplinary applications and potential to deal with important aspects of life, for instance, improving health, enhancing food resources, and resistance to divergent adverse environmental effects. Particularly in agriculture, the genetically modified plants have augmented resistance to harmful agents, enhanced product yield, and shown increased adaptability for better survival.
Recombinant DNA technology development and applications. B. Recombinant DNA refers to the creation of new combinations of DNA segments that.
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